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gsk3 inhibitor Understanding and defining these miRNA
2019-04-19
Understanding and defining these miRNA profiles helps to uncover the clinical usefulness of miRNAs. Numerous human clinical trials are currently evaluating miRNA therapeutics during various liver diseases, such as targeting miR-122 during chronic hepatitis C infection. Aside from therapeutics, the d
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There are important methodological issues affecting
2019-04-19
There are important methodological issues affecting the study of child mortality inequalities on the basis of survey data. McKinnon and colleagues relied on rigorous analytical tools to study these changes, and in some aspects—for example the graphical display of the statistical significance of chan
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dnmt Poor knowledge among caretakers of how to work with
2019-04-19
Poor knowledge among caretakers of how to work with disability-related disorders could also be an issue. For example, poor knowledge of how to correctly position a child with severe cerebral palsy could lead to inadequate feeding; at worst, these efforts can cause aspiration and even death. Social a
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In Grabowski and colleagues report that
2019-04-19
In , Grabowski and colleagues report that women consistently using DMPA were at nearly double the risk of acquiring herpes simplex virus type 2 (HSV2) compared with those using no contraception; in a sensitivity analysis limited to those whose main partner had HSV2, the risk increased by six times.
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n-phenylacetyl-l-prolylglycine ethyl ester Este autor nos pe
2019-04-19
Este autor nos permite la oportunidad de reflexionar la presencia de los sujetos colectivos a la hora de elaborar proyectos ético-políticos de la llamada “sociedad por venir”. Por ejemplo, cabe destacar en sus propuestas la preocupación sobre la justicia de las personas y de los colectivos desde la
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protoporphyrin ix br Introduction Human endogenous retroviru
2019-04-18
Introduction Human endogenous retroviruses (HERVs) are genetic remnants of ancient retroviral infections of the germ line produced during primate evolution which are now transmitted vertically. To date, approximately 8% of the human genome is composed of such retroviral sequences [1]. Most HERVs
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In silico prediction software SIFT PolyPhen CADD and other
2019-04-18
In silico prediction software, SIFT [51], PolyPhen2 [52], CADD [53], and other prediction systems are useful to evaluate a specific mutation which is detected in a patient. However, even if the in silico software predicts a mutation as pathogenic, we need to examine whether the genetic result is co
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br Case report A year old man
2019-04-18
Case report A 73-year-old man with HCM experienced palpitations for 6 months. A 12-lead electrocardiogram (ECG) obtained at a medical clinic showed a first-degree atrioventricular block (PR interval, 260ms), left ventricular hypertrophy (LVH) with strain-type negative T waves in V2–6 leads, and m
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br Remote monitoring advantages br What is obtained by remot
2019-04-18
Remote monitoring advantages What is obtained by remote monitoring? How should we act? Important factors at the time of informed consent Patients benefit greatly from RM, and they feel secure and safe because they feel connected to the hospital at all times. However, patients may have exces
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Immediate rollout of an effective and safe short
2019-04-18
Immediate rollout of an effective and safe short-course treatment regimen is essential for the attack phase of the visceral leishmaniasis elimination programme, which aims to reduce the incidence to less than one case per 10 000 W 54011 at risk. A single-dose liposomal amphotericin B regimen, which
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There are important methodological issues affecting the stud
2019-04-18
There are important methodological issues affecting the study of child mortality inequalities on the basis of survey data. McKinnon and colleagues relied on rigorous analytical tools to study these changes, and in some aspects—for example the graphical display of the statistical significance of chan
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Para el Movimiento Social Ind gena el lugar de
2019-04-18
Para el Movimiento Social Indígena, el lugar de la protesta es su propio territorio ancestral que es defendido frente vascular disrupting agent los actores armados. Así, el lugar adquiere por lo menos tres características: a) como sitio donde se realiza la acción colectiva, b) como el motivo y causa
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El ansia renovadora que suscita tambi n se crea
2019-04-18
El ansia renovadora que suscita también se crea y re-crea en los paratextos ilustrados, que en cierto modo también sugieren una performatividad discursiva aplicada a la realidad convulsa de México en la revista Futuro, que puede observarse en la imagen y que se ha titulado, “Defensores del orden”.
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Common and rare SCN A variants may
2019-04-17
Common and rare SCN10A variants may contribute to AF susceptibility [59,60]. SCN10A mutations (R14L and R1268Q) cause a loss of function of Nav1.5 current, which is expected to reduce excitability and lead to the development of the arrhythmogenic substrate responsible for BrS and AF. A common varian
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In humans the two primary bile acids CA
2019-04-17
In humans, the two primary bile acids CA and CDCA make up approximately 70%–80% of the total bile ambroxol hydrochloride pool. DCA is the major secondary bile acid, which may account for approximately 20% of the total bile acid pool. Among all bile acid species, the secondary bile acid LCA is highl
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